Evidence-based assessment of polyfunctional silicones' skin sensitisation Risk

Testing five prototype polyfunctional silicone materials for skin sensitisation potential yielded inconsistent results between the murine local lymph node assay (LLNA) and the guinea pig maximization test (GPMT). Despite all substances testing negative in the GPMT, four out of five showed weak to moderate potential in the LLNA. A thorough analysis, including workplace exposure and cosmetic use data, suggests these silicones do not pose a significant skin sensitisation risk to humans. The LLNA's suitability for such materials is questionable, indicating future testing strategies need careful, case-by-case evaluation.