Industry Update

Bioaccumulation of dodecamethylcyclohexasiloxane (D6) in fish

A new study on bioaccumulation of dodecamethylcyclohexasiloxane (D6) in fish.

Highlights of the study:

• Dietary uptake efficiency and BMF of D6 were 14 (3 SE) % and 0.38 (0.14 SE) kg lipid/kg lipid.

• Biotransformation rate constant of D6 was 0.016 (0.0026 SE) d−1.

• BCFs of D6 was estimated at 1909 (483SE) L/kg ww.

• Internal distribution of D6 is dominated by biotransformation.

• D6 bioaccumulates less than many very hydrophobic organochlorines.


To investigate the bioaccumulation behavior of dodecamethylcyclohexasiloxane (D6, CAS number: 540-97-6) in fish, an OECD-305 style dietary bioaccumulation study of D6 in rainbow trout was conducted in the presence of non-metabolizable reference chemicals. The dietary uptake absorption efficiency of D6 was 14 (3 SE) % and lower than that of the reference chemicals which ranged between 22 (2 SE) to 60 (8 SE) %. The concentration of D6 in the body of the fish showed a rapid 40% drop during the first day of the depuration phase, followed by a slower decline during the remainder of the depuration period. The overall depuration rate constant of D6 was 0.016 (0.0026 SE) d−1 and significantly greater than those of PCB153 and PCB209, which were not significantly different from zero. During the depuration phase, when fish body weight did not significantly change over time, depuration of D6 appears to be almost entirely due to biotransformation in the body of the fish. The biomagnification factor of D6 in rainbow trout was 0.38 (0.14 SE) kg-lipid kg-lipid−1, indicating a lack of biomagnification. The bioconcentration factor (BCF) of D6 in Rainbow trout was estimated at 1909 (483 SE) L kg−1 wet for natural waters of mostly oligotrophic lakes in Northern Canada with an average concentration of total organic carbon of 7.1 mg L−1. Comparing the bioaccumulation profile of D6 to that of 238 similar profiles for 166 unique chemicals indicates that the bioaccumulation capacity of D6 is markedly less than that of many very hydrophobic organochlorines.

The study can be found under this link.

For more information, please contact:
CES Manager, Evelyne Frauman // Email: // // @SiliconesEU